Background: Much of the re¬cent literature in this context has focused on tracing of highly multi¬drug-resistant (MDR) which might be disseminated in hospital en-vironment particularly through areas of highly susceptible patients like intensive care unit, burn and surgery wards and children’s lounge. The assessment of the disease burden is of priority for policymakers and public health officials to perform evidence of resource allocation and consequently to plan for the mitigation of threats to health. Methodology: The present work was conducted on 200 patients with wounds. Three hundreds were hospitalized and the other two hun¬dreds were non-hospitalized attended the outpatient’s clinic after operation for removal of stitches. Their ages ranged from 1-40 years. Wound swab was taken on the third postoperative day from hospitalized patients and on the seventh postoperative day from patients attended outpatient clinic. The isolated Staphylococcus aureus isolates were subjected to susceptibility diffusion discs of penicillin, benzathine penicillin, chloramphenicol, streptomycin, gentamicin, tetracycline, erythromycin, colistin, nitrofurantoin, Fucidin and clindamycin. Results: The present study revealed that the percentage matrices were not symmetrical as determined by the considered resistance, e.g. 30% of strains resistant to tetracycline were resistant to streptomycin while 100% of the strains resistant to streptomycin were resistant to tetracycline. It was also found that 20% of strains resistant to erythromycin were resistant to gentamicin, while 83.3% of strains resistant to gentamicin were resistant to erythromycin at the same time. Conclusions: It was seen that there were large numbers of trains resistant to pairs of antibiotics at the same time even of different antibiotics groups, e,g. colistain sulfate and erythromycin, erythromycin and tetracycline, clindamycin and penicillin. Nitrofurantoin showed no shared resistance with any of the antibiotics used in the present study.