Synthesis, Characterization and Antimicrobial Activities of Schiff Base Derived From Glyoximehydrazine and Substituted Furan and Their Metal (II) Complexes

A hydrazone Schiff base has been synthesized by the interaction of ethanolic solutions of antiglyoxime hydrazine with 2-acetyl-5-methylfuran to obtain the Schiff base L′. The complexes of Co(II), Ni(II) and Cu(II) of this Schiff base was synthesized and studied. The Schiff base and its metal(II) complexes were characterized based on solubility, percentage yield, elemental analysis, melting point/decomposition temperatures, infra- red spectral (FT-IR), conductivity measurement, magnetic susceptibility and water of crystallisation. Based on the results the prepared Schiff base and synthesized complexes are relatively soluble in most organic solvents but insoluble in distilled water. The melting point temperature of the ligand was 118oC while the decomposition temperature for metal complexes was found to be between 295 _320oC. The molar magnetic susceptibility of the complexes were in the range of 1.91 x 10-3 – 1.46 x 10-2erg.G-2mol-1. The molar conductance values of 2.00 – 3.00ohm-1cm2mol-1 indicating non electrolytic nature of the complexes. The spectral data of the Schiff base showed band at 1641cm-1, revealing the formation of the azomethine group in the Schiff base. A band between 776 and 791cm-1 indicate the metal nitrogen bond. The elemental analysis determination of the complexes and the Schiff base showed the metal ligand ratio of 1:2 (M:2L). The antibacterial and antifungal activities of the Schiff base and the metal(II) complexes were evaluated using disc diffusion method. The antibacterial assay was carried out on three pathogenic bacteria, Salmonella typhimurium, Proteus aureginosa and Staphylococcus aureus, and two fungi viz: Candida utilis and Saccharomyces cerevisiae. The Schiff base and the metal(II) compounds showed some antibacterial and antifungal activity.